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International Development Research @ Cambridge


Support for one large scale clinical trial to develop new and more effective second generation vaccines superior to the recently licenced malaria vaccine for human use (RTS,S).


The purpose of this Call for Proposals is to support one large-scale strategic action (clinical research activities) that is part of a bigger portfolio of clinical trials with the capacity to compare and select the most promising malaria vaccine candidates, and manage their progress through clinical development. 


The large-scale strategic action should have the potential to achieve maximum impact in the field and to make a significant contribution to the objectives of the EDCTP2 programme. In particular, the large-scale, strategic action should:

  • lead to the advancement of vaccine candidates through the development pipeline towards registration, leading to more effective prevention and clinical management of malaria in sub-Saharan Africa
  • contribute to the reduction of malaria mortality and morbidity in sub-Saharan Africa and thus contribute to achieving SDG 3 ‘Ensure healthy lives and promote well-being for all at all ages’

Proposals are expected to incorporate activities to enhance the capacity of existing clinical trial sites and/or develop new trial sites in sub-Saharan Africa for the conduct of vaccine trials. Successful applicants will be requested to coordinate their activities with other ongoing EDCTP and H2020 funded actions of relevance to malaria vaccine development.


Consortia comprising a minimum of three independent legal entities are eligible to apply. Two of the legal entities shall be established in two different European Partner States and one of the legal entities must be established in a sub-Saharan African country.

Level of funding

The budget of this call is €18 million (up to Up to 100% of eligible costs) for one project lasting 48-60 months.


For further information on remit, scope and application procedure please see the EDCTP website.

Welcome to Cambridge Global Challenges

Cambridge Global Challenges is the Strategic Research Initiative of the University of Cambridge that aims to enhance the contribution of its research towards addressing the Sustainable Development Goals (SDGs) by 2030, with a particular focus on the poorest half of the world’s population.


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